Prolonged dissolution of tablets prepared from pullulan mixed with konjac mannan.

Correlation between Compaction and Dissolution of Metoprolol Tartarate Tablets Prepared by Direct Compression Using Different Polymers

The investigation is to study the effect of polymers on compressibility and release of Metoprolol Tartarate from tablet through direct compression. Tablets were prepared by direct compression by mixing with commonly used polymers, Eudragit RL-100, Chitosan, Ethyl cellulose, Hydroxyethyl cellulose and hydroxypropylmethyl cellulose K-100 in 1:1 ratio. The compressibility parameters were estimated...

Dissolution of Intact, Divided and Crushed Circadin Tablets: Prolonged vs. Immediate Release of Melatonin

Circadin 2 mg prolonged-release tablet is the only licensed melatonin product available in the UK. Circadin is indicated for patients with primary insomnia aged 55 and over, but is more widely used "off-label" to treat sleep disorders especially in the paediatric population. Children and older people often have difficulty swallowing tablets and dividing the tablet is sometimes required to ease ...

From Microstructures of Tablets and Granules to Their Dissolution Behaviour

Introduction Dissolution testing is now an established and standardised method for measuring the performance of drug products (1). It allows results for different batches of the same product,similar products from different suppliers, or tests from different labs to be compared. It is, therefore,a useful tool for quality control and for formulation development,so much so that the FDA has made it...

Circadin Prolonged Release Tablets

Dissolution testing of orally disintegrating tablets.

For industrially manufactured pharmaceutical dosage forms, product quality tests and performance tests are required to ascertain the quality of the final product. Current compendial requirements specify a disintegration and/or a dissolution test to check the quality of oral solid dosage forms. These requirements led to a number of compendial monographs for individual products and, at times, the...